Flamingo Light Sheet Microscopes Rely on Motion Systems from PI

For the ambitious Flamingo light sheet microscopy project of the research lab around Prof. Jan Huisken at the Morgridge Institute for Research (Madison, WI), Physik Instrumente (PI) supplies linear and rotary stages. These are used for positioning and moving samples in the microscopes. Dr. Thomas Bocher, Head of Segment Marketing Life Science & Microscopy at PI, is delighted that PI was invited to become one of the sponsors of this project: "The use of our precision drives in the Flamingo project is a further proof of their high acceptance even in the most demanding microscopy applications". Key factors are the compact design, reliability, high precision and speed of the motion modules.

"We aim to democratize high-end light microscopy, bringing it to campuses and labs for free," explains Professor Jan Huisken, co-inventor of light sheet microscopy and Director of the Medical Engineering Department at the Morgridge Institute for Research. The project, which is supported by several sponsors, turns the idea of central research facilities upside down and makes travelling with sensitive samples obsolete.

Up to now, two complete systems have been set up; for the coming months and years, Huisken and his team are planning to build several dozen Flamingo-type microscopes. The name derives from the shape of the basic version of the microscope, which reminds us of the bird standing on one leg.

In Light Sheet Fluorescence Microscopy (LSFM), illumination and detection are two separate optical systems that are oriented perpendicular to each other. A laser beam is focused to form a light sheet that illuminates a thin plane within the sample. The fluorescent light that is emitted in this plane is captured and detected by an objective lens. "LSFM is a very powerful and flexible platform for gentle in vivo imaging, offering low phototoxicity and fast image acquisition," Jan Huisken summarizes the advantages of the technology. Because of the gentle "treatment" of the sample, LSFM is predestined for the examination of living organisms.

PI (Physik Instrumente) Ltd

Trent House, University Way
Cranfield Technology Park
Bedford
MK43 0AN
UNITED KINGDOM

+44 (0)1234 756360

info@pi.ws

www.pi.ws

More products
Individual service for signal integrity
The demands on connection technology performance are constantly increasing. By providing customised support, Phoenix Contact helps customers select connection components to ensure the highest possible signal integrity.
Aveva MES rises in the leader ranks of the latest Gartner report
Aveva’s Manufacturing Execution Systems (MES) offering, which is deployed in the UK & Ireland by AVEVA Select partners SolutionsPT, has been recognised as a global leader in industrial software in the latest 2022 Gartner Magic Quadrant for Manufacturing Execution Systems.
Siemens selected by Microsoft for RAMP Programme
Siemens Digital Industries Software has been selected to participate in the Rapid Assured Microelectronics Prototypes (RAMP) Phase II initiative.
Thomson Industries exhibits linear actuators for the marine industry
Thomson Industries will be exhibiting at the 30th Shipbuilding, Machinery and Marine Technology (SMM) trade fair in Hamburg in September, showcasing its comprehensive line of electric linear actuators for marine applications.
Harwin and MSA Components sign German distribution deal
Harwin is bringing greater strength to its German supply chain through a new strategic partnership with MSA Components. The agreement allows MSA to offer all the latest products from Harwin’s extensive portfolio.
Mould making at Emka for injection moulding of plastics and metals
Emka reports that it is now one of the top three mould makers in Europe – producing 900 moulds a year for plastic injection, including polyamide/glass and Grivery, as well as zinc and aluminium die casting.
Kontron receives VDC Research’s Gold Award for vendor satisfaction
Kontron has been recognised for outstanding customer satisfaction. The company has received the Gold Vendor Satisfaction Award for IoT and Embedded Hardware technology from VDC Research.
Mouser wins Vishay Distributor of the Year Award
Mouser Electronics has received the 2021 High Service Distributor of the Year award from Vishay Intertechnology, one of the world’s largest manufacturers of discrete semiconductors and passive electronic components.
What changes does the new machinery regulation bring?
As the machinery regulation replaces machinery directive 2006/42/EC, Dirk Meyer, specialist engineer solution architect at Eaton, looks at what is changing.
Klüber Lubrication receives Schaeffler Supplier Award 2022
Schaeffler has awarded Klüber Lubrication with the Supplier Award 2022 in the field of quality. The jury emphasised in particular the global supplier's strong commitment to the compliance with quality standards.

Login / Sign up